TN-16

SKU: orb1299494

Description

TN-16 is a potent small molecule inhibitor of microtubule polymerization, exhibiting activity in the sub-micromolar range (IC50: 0.4-1.7 µM). It is a valuable research tool for studying cytoskeleton dynamics, cell division, and mitosis in both cellular and biochemical assays.

Research Area

Signal Transduction

Key Properties

• CAS Number: 33016-12-5
• MW: 306.36
• Purity: 99.54% (May vary between batches)
• Formula: C₁₉H₁₈N₂O₂
• SMILES: C(NC1=CC=CC=C1)(C)=C2C(=O)C(CC3=CC=CC=C3)NC2=O
• Target: Microtubule Associated
• Solubility: DMSO:9 mg/mL (29.38 mM)

Bioactivity

• Target IC50:
  Microtubule polymerization:0.4-1.7 µM
• In Vitro:
  TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells.TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

microtubule polymerization, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, inhibit, Inhibitor, TN 16, TN16, TN-16

Compound Identifiers

PubChem CID

135427136