TMX-2172

SKU: orb2815195

Description

TMX-2172 is a selective CDK2/CDK5 degrader with minimal off-target effects, demonstrating potent anti-proliferative activity in CCNE1-high ovarian cancer models like OVCAR8 cells. This lead compound supports research into targeted protein degradation as a therapeutic strategy for cyclin E1-amplified cancers in both in vitro and in vivo settings.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2488892-09-5
• MW: 970.82
• Formula: C₄₁H₄₅BrFN₉O₁₁S
• SMILES: O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3C)S(=O)(=O)NCCOCCOCCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6
• Target: PROTACs,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155184605