TMPA

SKU: orb1309002

Description

TMPA is a small molecule antagonist that disrupts the interaction between the nuclear receptor Nur77 (NR4A1) and the kinase LKB1 (STK11). This compound is a valuable research tool for investigating Nur77-LKB1 signaling in metabolic regulation, cancer, and inflammation, with utility in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Musculoskeletal & Connective Tissue Research, Signal Transduction

Key Properties

• CAS Number: 1258275-73-8
• MW: 380.48
• Purity: 98.08% (May vary between batches)
• Formula: C₂₁H₃₂O₆
• SMILES: CCCCCCCC(=O)c1cc(OC)c(OC)c(OC)c1CC(=O)OCC
• Target: AMPK,NR4A
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.67 mM);DMSO:90 mg/mL (236.54 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPKα, AMPK, AMP-activated protein kinase, Inhibitor, hepatic LO2, Nur77, LKB1, inhibit, TMPA, T cells, type II diabetes

Compound Identifiers

PubChem CID

60146245