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TMP778

SKU: orb1708347

Description

TMP778 is a potent and selective inverse agonist of the nuclear receptor RORγt, demonstrating an IC50 of 7 nM in a FRET-based assay. This small molecule is a valuable research tool for investigating Th17 cell biology and autoimmune pathologies in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1422053-04-0
MW494.58
FormulaC31H30N2O4
SMILESCc1noc(C)c1[C@H](O)c1cc2cc(CC(=O)N[C@@H](c3ccccc3)c3ccc(C)cc3C)ccc2o1
TargetOthers,ROR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • TMP-778 [orb1309003]

    99.68%

    1422171-08-1

    494.58

    C31H30N2O4

    1 ml x 10 mM (in DMSO), 1 mg, 5 mg, 50 mg
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Key Properties

No computed properties available.

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TMP778 (orb1708347)

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