TMC353121

SKU: orb1706528

Description

TMC353121 is a small molecule RSV fusion inhibitor that suppresses viral replication and reduces the production of key pro-inflammatory cytokines and chemokines, including TNF-α, IL-6, and MIP1-α. It is a valuable research tool for studying RSV pathogenesis and antiviral mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 857066-90-1
• MW: 558.71
• Purity: ≥98% (May vary between batches)
• Formula: C₃₂H₄₂N₆O₃
• SMILES: Cc1ccc(CCCO)c(NCc2ccc3nc(NCCCN4CCOCC4)n(Cc4nc(C)ccc4O)c3c2)c1
• Target: RSV,IL Receptor,TNF
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.58 mM);DMSO:30 mg/mL (53.7 mM)

Bioactivity

• Target IC50:
  RSV:9.9 (pEC50)
• In Vivo:
  After single subcutaneous administration and repeated administration 24 hours post-intranasal RSV inoculation, TMC353121 dose-dependently reduces viral titers in bronchoalveolar lavage fluid.
  Read more...
• In Vitro:
  TMC353121 is an effective RSV fusion inhibitor, active against wild-type RSV (strain LO) with a 50% effective concentration (EC50) of 0.07 ng/mL in HeLaM cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RSV, TNF-α, TMC 353121, TMC353121, TMC-353121, ILReceptor, IL-6, IL Receptor

Compound Identifiers

PubChem CID

11249932