TM2 TEAD inhibitor

SKU: orb1979922

Description

TM2 is a potent, reversible TEAD inhibitor that blocks auto-palmitoylation (IC₅₀: 38 nM TEAD4) and disrupts TEAD-YAP transcriptional activity. It demonstrates significant antiproliferative effects in YAP-dependent cancer cells and potently inhibits the growth of YAP-driven liver organoids in vitro, supporting its investigation as an anticancer therapeutic.

Research Area

Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1008768-41-9
• MW: 435.57
• Purity: 99.91% (May vary between batches)
• Formula: C₂₆H₃₃N₃O₃
• SMILES: O=C(NC=1C=CC=CC1)N2CCN(C(=O)C=3C=CC=C(OCCC4CCCCC4)C3)CC2
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TEAD-IN-8

Compound Identifiers

PubChem CID

68301145