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TLR8 antagonist-1

SKU: orb2893625

Description

TLR8 antagonist 1 (Compound 10) is a selective small molecule inhibitor that blocks TLR8-mediated signaling by reducing MyD88 recruitment, thereby suppressing downstream NF-κB and IRF activation. This compound serves as a valuable research tool for studying TLR8-driven inflammatory responses in both cellular and animal models of autoimmune and infectious diseases.

Research Area

Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1111460-83-3
MW387.47
FormulaC21H29N3O4
SMILESO=C(NC1CCN(CC)CC1)C2=CC=C(OCC=3C(=NOC3C)C)C(OC)=C2
TargetTLR,MyD88,NF-κB

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information