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TLR8 agonist 9

SKU: orb2564597

Description

TLR8 agonist9 (Compound II-77) is a potent and plasma-stable TLR8 agonist (EC50 0.25-1 µM) that induces TNFα secretion. It demonstrates significant antitumor efficacy in vivo, achieving 97% tumor growth inhibition in an MC38-HER2 mouse model, supporting its use in immuno-oncology and inflammation research.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number3034750-61-0
MW725.79
FormulaC38H43N7O8
SMILESO=C1C=CC(=O)N1CC2OCC(C(=O)N3CC4=CC(=CN=C4CC3)NC(=O)C5(C=6C=CC=7C=C(C(=O)N(CCO)CCC)CC(=NC7C6)N)CC5)CO2
TargetTLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

TLR8 agonist 9 (orb2564597)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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