TLR8 agonist 9

• Catalog Number: orb2564597
• Category: Small Molecules
• Description: TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.
• Purity: 98.00%
• MW: 725.79
• CAS Number: 3034750-61-0
• Formula: C₃₈H₄₃N₇O₈
• SMILES: O=C1C=CC(=O)N1CC2OCC(C(=O)N3CC4=CC(=CN=C4CC3)NC(=O)C5(C=6C=CC=7C=C(C(=O)N(CCO)CCC)CC(=NC7C6)N)CC5)CO2
• Storage: -20°C
• Note: For research use only