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TLR8 agonist 8
Catalog Number: orb2564441
| Catalog Number | orb2564441 |
|---|---|
| Category | Small Molecules |
| Description | TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%. |
| Purity | 98.00% |
| MW | 1014.14 |
| CAS Number | 3034750-58-5 |
| Formula | C53H63N11O10 |
| SMILES | C(NC=1C=C2C(=NC1)CCN(C(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=O)=O)=O)C2)(=O)C5(CC5)C=6C=C7C(=CC6)C=C(C(N(CCC)CCO)=O)CC(N)=N7 |
| Storage | -20°C |
| Note | For research use only |
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