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TLR8 agonist 8

SKU: orb2564441

Description

TLR8 agonist8 (Compound II-72) is a stable small molecule TLR8 agonist with an EC50 of 0.25-1 µM, inducing TNFα secretion. It demonstrated potent in vivo antitumor efficacy in a MC38-HER2 mouse model, achieving 89% tumor growth inhibition, supporting its use in immuno-oncology research.

Research Area

Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3034750-58-5
MW1014.14
FormulaC53H63N11O10
SMILESC(NC=1C=C2C(=NC1)CCN(C(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=O)=O)=O)C2)(=O)C5(CC5)C=6C=C7C(=CC6)C=C(C(N(CCC)CCO)=O)CC(N)=N7
TargetTLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

TLR8 agonist 8 (orb2564441)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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