TLR7/8/9-IN-1

SKU: orb1303500

Description

TLR7/8/9-IN-1 is a potent and selective small molecule inhibitor of Toll-like receptors 7, 8, and 9, demonstrating an IC50 of 43 nM. This compound is a valuable research tool for studying TLR-mediated immune signaling in both cellular and animal models of autoimmune and inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2180127-82-4
• MW: 435.6
• Purity: 99.56% (May vary between batches)
• Formula: C₂₇H₃₇N₃O₂
• SMILES: CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1ccc(OC)c(OC)c1
• Target: TLR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.3 mM);DMSO:6.11 mg/mL (14.03 mM)

Bioactivity

• Target IC50:
  TLR7/8/9:43 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, TLR7/8/9, TLR7/8/9 IN 1, TLR7/8/9IN1, TLR-7/8/9-IN-1, TLR7/8/9-IN-1, Toll-like Receptor (TLR)

Compound Identifiers

PubChem CID

134230357