TLR7/8 agonist 1 dihydrochloride

SKU: orb1220903

Description

TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.(In Vitro):TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.

Research Area

Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 1620278-72-9
• MW: 432.39
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇Cl₂N₅
• SMILES: Cl.Cl.CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccc(CN)cc1
• Target: TLR
• Solubility: DMSO: 70 mg/mL (161.89 mM)

Bioactivity

• In Vitro:
  TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TLR7/8 agonist-5d

Quick Database Links

Gene Symbol

TLR