TLR7 antagonist-1

SKU: orb3211336

Description

TLR7antagonist-1 (Compound 44#) is an orally bioavailable and selective TLR7 antagonist with an IC50 value of 0.3 nM for TLR7. It specifically binds to TLR7, inhibiting its activation and downregulating the c-Rel signaling pathway. TLR7antagonist-1 also reduces the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α and alleviates psoriasiform lesions induced by Imiquimod. This compound is applicable for psoriasis-related research.

Key Properties

• CAS Number: 3104353-70-7
• MW: 455.90
• Formula: C₂₁H₂₅ClF₃N₅O
• SMILES: Cl.FC(F)(F)C=1C=C(C=NC1N2CCC(N)(C)CC2)C=3C=C(OC)C4=NC(=CN4C3)C
• Target: TLR,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR,Interleukin