TLC-2716

SKU: orb3210735

Description

TLC-2716 is an orally active LXRα and LXRβ inhibitor, localized to the intestines and liver, with EC50 values of 7 nM and 15 nM, respectively. It suppresses the transcriptional activity of LXRα/β, downregulates genes involved in lipogenesis, lipid absorption, and lipoprotein metabolism, while preserving peripheral cholesterol reverse transport. TLC-2716 reduces lipid accumulation, inhibits the expression of inflammatory and fibrotic genes, enhances the clearance of triglyceride-rich lipoproteins, and improves glucose homeostasis and insulin sensitivity. In animal models and humanized liver mice, TLC-2716 lowers serum and hepatic triglyceride levels, plasma cholesterol levels, and other atherosclerosis-inducing lipid markers. It is applicable in research related to dyslipidemia and associated cardiometabolic disorders.

Key Properties

• Target: Liver X Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Liver X Receptor