TL4-12

SKU: orb1701516

Description

TL4-12 is a research chemical that functions as a MAP4K2/GCK inhibitor, targeting IKZF1 and BCL-6 to suppress proliferation and induce apoptosis in multiple myeloma cells. It is a useful tool for in vitro studies investigating MM pathogenesis and potential therapeutic strategies.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1620820-12-3
• MW: 500.52
• Purity: 99.05% (May vary between batches)
• Formula: C₂₅H₂₇F₃N₆O₂
• SMILES: O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2CCN(C)CC2)C3=CC=C(C(OC4=NC=NC(=C4)NC)=C3)C
• Target: Bcl-2 Family,IKZF,Bcl-6,MAPK,Immunology/Inflammation related,Apoptosis
• Solubility: DMSO:5.04 mg/mL (10.07 mM)

Bioactivity

• In Vitro:
  The GCK inhibitor TL4-12 downregulates IKZF1 and BCL-6 in a dose-dependent manner, resulting in proliferation inhibition and induction of apoptosis in multiple myeloma cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, BCL, GCK, Inflammation related, Inflammationrelated, Immunologyrelated, Immunology related, TL412, TL-4-12, TL4-12, TL4 12

Compound Identifiers

PubChem CID

134812827