TKL002

SKU: orb3173008

Description

TKL002 is a blood-brain barrier-permeable inhibitor of the CTH/H₂S/NF-κB/EMT signaling axis. It induces G2/M phase cell cycle arrest and apoptosis in glioblastoma cells. TKL002 also inhibits the migration and invasion of glioblastoma cells by upregulating E-cadherin and downregulating N-cadherin and vimentin expression, and is used in glioblastoma research.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3098518-95-4
• MW: 420.40
• Purity: 99.99% (May vary between batches)
• Formula: C₂₁H₂₀F₄N₄O
• SMILES: FC1=CC(=CC=C1N2CCNCC2)NC=3N=C4C=CC(OC)=CC4=C(C3)C(F)(F)F
• Target: Caspase,Bcl-2 Family,Cadherin,NF-κB,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Bcl-2 Family,Cadherin,NF-κB,Apoptosis