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TK-129

SKU: orb1689316

Description

TK-129 is a potent, orally bioavailable KDM5B inhibitor (IC50 = 44 nM) with a low-toxicity profile. It exhibits cardioprotective effects by disrupting the KDM5B-associated Wnt pathway, reducing myocardial fibrosis and remodeling in isoprenaline-induced in vivo models, and attenuating Ang II-induced cardiac fibroblast activation in vitro for cardiovascular disease research.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

MW305.38
FormulaC15H23N5O2
TargetHistone Demethylase,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • TK-129 [orb2703220]

    >98%

    3031476-73-7

    305.38

    C15H23N5O2

    100 mg, 250 mg, 1 g
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Protocol Information

TK-129 (orb1689316)

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