TJ-M2010-5

SKU: orb1297890

Description

TJ-M2010-5 is a small molecule MyD88 inhibitor that suppresses signaling by binding to the TIR domain and blocking its homodimerization. It is a valuable research tool for investigating myocardial ischemia/reperfusion injury, as well as other inflammatory conditions, in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1357471-57-8
• MW: 406.6
• Purity: >98%
• Formula: C₂₃H₂₆N₄OS
• SMILES: O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1nc(cs1)-c1ccccc1
• Target: TLR (Toll-like receptor)
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

• In Vivo:
  TJ-M2010-5 statistically significantly decreases TNF-α, IL-6, G-CSF, MIP-1β, IL-11, IL-17A, IL-22, and IL-23 serum concentrations in mice at both two and seven weeks postinduction. In a 10-week CAC mouse model, TJ-M2010-5 statistically significantly reduces AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, results in 0% mortality of treated mice, decreases cell proliferation, and increased apoptosis in colon tissue.
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• In Vitro:
  TJ-M2010-5 (0 μM, 5 μM, 10 μM, 20 μM and 30 μM) prevents B cell proliferation and induces B cells apoptosis after stimulation with R848 (500 ng/mL).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TJ-M-2010-5, TJ-M2010-5, TJM20105, TJ M2010 5, reoxygenation, reperfusion, remodeling, differentiation, Anoxia, Inhibitor, injury, factor, myeloid, MyD88, MyD88,TLR, myocardial, ischemia, inhibit, MIRI

Compound Identifiers

PubChem CID

71542350