Tirucallol

SKU: orb1297618

Description

Tirucallol is a natural small molecule isolated from Euphorbia lactea with demonstrated topical anti-inflammatory activity in vivo. Its mechanism is associated with the inhibition of neutrophil migration, making it a candidate for research in inflammation and immunology.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 514-46-5
• MW: 426.72
• Purity: 99.98% (May vary between batches)
• Formula: C₃₀H₅₀O
• SMILES: [H][C@]1(CC[C@]2(C)C3=C(CC[C@@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@]1([H])CC3)[C@@H](C)CCC=C(C)C
• Target: Prostaglandin Receptor,NO Synthase,NOS
• Solubility: DMSO:4.27 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiinflammatory, Euphorbia, Inhibitor, latex, lacteal, NO Synthase, inhibit, NOS, NOSynthase, Prostaglandin Receptor, ProstaglandinReceptor, PGE, Tirucallol, tetracyclic, triterpene

Compound Identifiers

PubChem CID

101257