Tirbanibulin Mesylate

SKU: orb1308150

Description

Tirbanibulin Mesylate

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1080645-95-9
• MW: 527.63
• Purity: 99.42%
• Formula: C₂₇H₃₃N₃O₆S
• SMILES: CS(O)(=O)=O.O=C(Cc1ccc(cn1)-c1ccc(OCCN2CCOCC2)cc1)NCc1ccccc1
• Target: Src,Microtubule Associated
• Solubility: DMSO:99 mg/mL (187.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.25 mM)

Bioactivity

• Target IC50:
  Src:13 nM(in PLC/PRF/5 cells)|Src:26 nM(in Hep3B cells)|Src:60 nM（in HepG2 cells)|Src:9 nM (GI50, in HuH7 cells)
• In Vivo:
  In pre-clinical animal models of cancer, Tirbanibulin Mesylate (p.o.) is shown to inhibit Primary tumor growth and to suppress metastasis.
• In Vitro:
  Tirbanibulin Mesylate is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells wit the T3151 mutation. Tirbanibulin Mesylate displays steep dose-response curves against Huh7 (GI5 = nM), PLC/PRF/5 (GI5 = 3 nM), Hep3B (GI5 = 6 nM), and HepG2 (GI5 = 0 nM), four hepatic cell cancer (HCC) cell lines. Tirbanibulin Mesylate is evaluated in engineered Src drove cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, KX2-391 Mesylate, KX-01, KX01 Mesylate, KX-01 Mesylate, KX2-391, KX 01, KX 01 Mesylate, KX01, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, Inhibitor, Tirbanibulin, Tirbanibulin Mesylate, Src

Compound Identifiers

PubChem CID

25100013