Tirabrutinib hydrochloride

SKU: orb1309295

Description

Tirabrutinib hydrochloride

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1439901-97-9
• MW: 490.94
• Purity: 99.95%
• Formula: C₂₅H₂₃ClN₆O₃
• SMILES: Cl.CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O
• Target: Apoptosis,BTK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.07 mM);DMSO:95 mg/mL (193.51 mM)

Bioactivity

• Target IC50:
  BTK:2.2 nM|ERBB2:7.31 μM|BLK:0.3 μM|JAK3:5.52 μM|TXK:92 nM|ERB4:0.77 μM|BMX kinase:6 nM|TEC:48 nM|EGFR:3.02 μM
• In Vivo:
  Parental TMD8 mice were treated with tirabrutinib (6, 20 mg/kg; p.o.) to confirm whether tirabrutinib remains active in vivo. RESULTS 0.012% of tirabrutinib resulted in tumor remission in mice.
• In Vitro:
  METHODS: Tirabrutinib hydrochloride (0.1-1000 nM or 0.001-100 nM; 72 h) was used to treat DLBCL cell lines SU-DHL-6 and OCI-LY10 to observe the anti-tumor effect on cells. RESULTS The IC50 values ​​of Tirabrutinib hydrochloride against SU-DHL-6 and OCI-LY10 cell lines were 9.127 μM, and 17.10 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bruton tyrosine kinase, BTK, Btk, B cells, autoimmune disorders, Apoptosis, inhibit, PCNSL, ONO 4059, ONO4059, ONO-4059, ONO-4059 (hydrochloride), GS4059, GS-4059, GS-4059 (hydrochloride), GS 4059, haematological malignancies, Inhibitor, Tirabrutinib, Tirabrutinib Hydrochloride, Tirabrutinib hydrochloride

Compound Identifiers

PubChem CID

71571562