TIQ-A

SKU: orb1302184

Description

TIQ-A is a small molecule inhibitor of PARP1, an enzyme activated by DNA damage and implicated in pathological processes like ischemia-reperfusion injury and inflammation. This compound is a valuable research tool for studying base excision repair and has been utilized in both in vitro and in vivo models of related diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 420849-22-5
• MW: 201.24
• Purity: 99.75%
• Formula: C₁₁H₇NOS
• SMILES: O=c1[nH]c2sccc2c2ccccc12
• Target: PARP
• Solubility: DMSO:55 mg/mL (273.31 mM)

Bioactivity

• Target IC50:
  PARP10:>10 μM|TNKS2:24 nM|PARP2:210 nM|PARP15:230 nM|PARP14:>10 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADP-ribosylation, ADP-ribosyltransferase, Inhibitor, inhibit, PARP, PARP1, poly ADP ribose polymerase, poly-ART, TIQ A, TIQA, TIQ-A, tankyrases

Compound Identifiers

PubChem CID

9899130