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Tipiracil

SKU: orb1909020

Description

Tipiracil is a thymidine phosphorylase inhibitor used in research to enhance the bioavailability and antitumor efficacy of trifluridine. This combination is studied in preclinical models of colorectal and gastric cancers for its potential in advanced or metastatic disease.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number183204-74-2
MW242.66
Purity99.81% (May vary between batches)
FormulaC9H11ClN4O2
SMILESO=C1NC(=O)C(Cl)=C(N1)CN2C(=N)CCC2
TargetDNA/RNA Synthesis,Others,Nucleoside Antimetabolite/Analog
SolubilityH2O:0.8 mg/mL (3.3 mM);DMSO:< 1 mg/mL (insoluble)

Bioactivity

In Vitro
Tipiracil functions as a thymidine phosphorylase inhibitor, enhancing trifluridine's efficacy by impeding its metabolism via thymidine phosphorylase. This synergistic action facilitates the use of the Trifluridine-Tipiracil combination as an innovative oral treatment for metastatic colorectal cancer . Additionally, Tipiracil fortifies the stability of FTD by mitigating its first-pass degradation through its inhibitory action on thymidine phosphorylase .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Tipiracil (orb1909020)

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Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 140.00
50 mg
$ 180.00
100 mg
$ 220.00
500 mg
$ 440.00
DispatchUsually dispatched within 6-8 weeks
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