Tipiracil

SKU: orb1909020

Description

Tipiracil is a thymidine phosphorylase inhibitor used in research to enhance the bioavailability and antitumor efficacy of trifluridine. This combination is studied in preclinical models of colorectal and gastric cancers for its potential in advanced or metastatic disease.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 183204-74-2
• MW: 242.66
• Purity: 99.82%
• Formula: C₉H₁₁ClN₄O₂
• SMILES: O=C1NC(=O)C(Cl)=C(N1)CN2C(=N)CCC2
• Target: Others,Nucleoside Antimetabolite/Analog,DNA/RNA Synthesis
• Solubility: H2O:0.8 mg/mL (3.3 mM);DMSO:< 1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  Tipiracil functions as a thymidine phosphorylase inhibitor, enhancing trifluridine's efficacy by impeding its metabolism via thymidine phosphorylase. This synergistic action facilitates the use of the Trifluridine-Tipiracil combination as an innovative oral treatment for metastatic colorectal cancer . Additionally, Tipiracil fortifies the stability of FTD by mitigating its first-pass degradation through its inhibitory action on thymidine phosphorylase .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

6323266