Tipifarnib (S enantiomer)

SKU: orb1307666

Description

Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-configured enantiomer of the potent farnesyltransferase inhibitor Tipifarnib, which exhibits an IC50 of 0.6 nM. This compound is used in research to study oncology pathways, particularly in hematologic malignancies and solid tumors, in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 192185-71-0
• MW: 489.4
• Purity: 99.05%
• Formula: C₂₇H₂₂Cl₂N₄O
• SMILES: Cn1cncc1[C@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
• Target: Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM);DMSO:25 mg/mL (51.08 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tipifarnib, Tipifarnib (S enantiomer), Tipifarnib S enantiomer, R 115777, R115777, R-115777, (S)-(-)-R-115777, (S)-Tipifarnib, inhibit, IND-58359 S enantiomer, Inhibitor, Farnesyl Transferase, Ftase

Compound Identifiers

PubChem CID

9935249