TIP48/49-IN-1

SKU: orb3028754

Description

TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC).

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1807337-58-1
• MW: 536.022
• Formula: C₂₈H₃₀ClN₅O₄
• SMILES: O(CC)C1=C(C=2OC(=NN2)[C@@H]3C[C@H](C(NC=4C(=O)N(N(C)C4C)C5=CC=CC=C5)=O)CCC3)C=C(Cl)C=C1
• Target: Proton pump

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Proton pump