Tiopronin

SKU: orb1307968

Description

Tiopronin (Acadione) is a thiol derivative of glycine used in research to study cystinuria. It lowers urinary cystine concentration, thereby inhibiting cystine stone formation. This compound is applied in biochemical and pharmacological studies, including in vitro assays and in vivo models of renal stone disease.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1953-02-2
• MW: 163.19
• Purity: 99.87% (May vary between batches)
• Formula: C₅H₉NO₃S
• SMILES: C(NCC(O)=O)(C(C)S)=O
• Target: ROS
• Solubility: DMSO:70 mg/mL (428.95 mM);Ethanol:30 mg/mL (183.83 mM);H2O:29 mg/mL (177.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.26 mM)

Bioactivity

• In Vivo:
  Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level.
• In Vitro:
  Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acadione, Captimer, inhibit, Inhibitor, Thiopronine, Tiopronin, ROS

Compound Identifiers

PubChem CID

5483