Timosaponin AIII

SKU: orb1304242

Description

Timosaponin AIII is a bioactive steroidal saponin that induces autophagy and subsequent apoptosis in cancer cells, such as HeLa cells, via mTORC1 inhibition and ER stress induction. Its pro-apoptotic effects are selective for tumor cells, making it a valuable tool for studying autophagy, apoptosis, and cancer cell death mechanisms in vitro.

Research Area

Neuroscience, Signal Transduction

Key Properties

• CAS Number: 41059-79-4
• MW: 740.92
• Purity: 99.61%
• Formula: C₃₉H₆₄O₁₃
• SMILES: C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@]5(C)[C@](CC4)(C[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@@H](O)[C@@H](CO)O6)CC5)[H])[H])[H])[H])(O[C@@]8([C@H]3C)CC[C@H](C)CO8)[H])[H]
• Target: mTOR,Cholinesterase (ChE)
• Solubility: DMSO:250 mg/mL (337.42 mM)

Bioactivity

• Target IC50:
  mTORC1(MDAMB231):6 μM|mTORC1(BT474 cells):2.5 μM

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), AChE, AneMarsaponin A3, mTORC1, inhibit, Filiferin B, Inhibitor, Timosaponin AIII, Timosaponin A3

Compound Identifiers

PubChem CID

15953793