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Timcodar mesylate
Catalog Number: orb2564361
| Catalog Number | orb2564361 |
|---|---|
| Category | Small Molecules |
| Description | Timcodar mesylate (VX-853-2) and its analog VX-710 function as inhibitors of mammalian multidrug-resistant bacterial efflux pumps, specifically blocking the efflux of ethidium bromide in Staphylococcus aureus. This capability suggests that Timcodar mesylate may boost the efficacy of antibiotics by impeding the bacterial efflux pumps, therefore lowering the minimum inhibitory concentrations of certain antibiotics against Gram-positive pathogens including Staphylococcus aureus, Enterococcus, and Streptococcus pneumoniae. |
| MW | 941.50 |
| CAS Number | 183313-30-6 |
| Formula | C45H53ClN4O12S2 |
| SMILES | CS(=O)(O)=O.ClC(C=C1)=CC=C1C[C@H](N(C)C(C(C2=CC(OC)=C(C(OC)=C2)OC)=O)=O)C(N(CC3=CC=CC=C3)C(CCC4=CC=NC=C4)CCC5=CC=NC=C5)=O.CS(=O)(O)=O |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
