Tilfrinib

SKU: orb1706534

Description

Tilfrinib is a potent and selective Brk (Breast Tumor Kinase) inhibitor with an IC50 of 3.15 nM. It demonstrates anti-proliferative activity in cellular assays and has shown anti-tumor efficacy in vivo, making it a valuable tool for oncology research targeting Brk-dependent signaling pathways.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1600515-49-8
• MW: 275.3
• Purity: 99.73% (May vary between batches)
• Formula: C₁₇H₁₃N₃O
• SMILES: Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
• Target: BTK
• Solubility: DMSO:112.5 mg/mL (408.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.53 mM)

Bioactivity

• Target IC50:
  Brk:3.15 nM
• In Vitro:
  Tilfrinib is against MCF7, HS-578/T, and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 µM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRK, Brk, Tilfrinib

Compound Identifiers

PubChem CID

76332983