Tigloylgomisin H

SKU: orb1297188

Description

Tigloylgomisin H is a novel monofunctional inducer that activates the Nrf2-ARE pathway, specifically upregulating phase II enzymes like quinone reductase in Hepa1c1c7 cells. Its role in chemoprevention makes it a candidate for research in liver cancer prevention, applicable in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 66069-55-4
• MW: 500.58
• Purity: 99.95% (May vary between batches)
• Formula: C₂₈H₃₆O₈
• SMILES: O(C(C(=CC)C)=O)C1=C2C=3C(=CC(OC)=C(OC)C3OC)CC(C)(O)C(C)CC2=CC(OC)=C1OC
• Target: Nrf2
• Solubility: DMSO:50 mg/mL (99.88 mM)

Bioactivity

• In Vitro:
  In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tigloylgomisin H, Nrf2, inhibit, Inhibitor

Compound Identifiers

PubChem CID

74491148