Tiger17 TFA

• Catalog Number: orb1980059
• Category: Small Molecules
• Description: Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 µg/ml concentrations, and promotes HaCaT cell migration at 20 µg/ml. Additionally, Tiger17 augments RAW 264.7 macrophages' recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 µg/ml, it accelerates wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.
• Purity: 98.00%
• MW: 1376.70
• Biological Activity: Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 µg/ml concentrations, and promotes HaCaT cell migration at 20 µg/ml. Additionally, Tiger17 augments RAW 264.7 macrophages' recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 µg/ml, it accelerates wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.
• Formula: C₆₂H₉₇N₂₁O₁₁S₂.XCF₃COOH
• SMILES: O=C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N2[C@](CCC2)([H])C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@H](CSSC4)C(N[C@H](C(N)=O)CC5=CN=CN5)=O)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)=O)CCCCN)=O)=O)CCCCN)[C@H]4NC([C@@H](N)CC6=CNC7=CC=CC=C67)=O.OC(C(F)(F)F)=O
• Storage: -20°C
• Note: For research use only