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Tie2 Inhibitor 7

SKU: orb1693504

Description

Tie2 Inhibitor 7 is a potent small molecule antagonist of the Tie2 receptor tyrosine kinase, exhibiting a Ki of 1.3 μM and an IC50 of 0.3 μM against Ang1-induced autophosphorylation. It effectively blocks downstream signaling, inhibiting endothelial tube formation in vitro and choroidal neovascularization in vivo rat models, making it a valuable research tool for angiogenesis studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1020412-97-8
MW529.63
FormulaC31H35N3O5
SMILESC(O)(=O)C1=CC(C2=CC=C(CN(C(OC3=CC=C(C)C=C3)=O)CC(N[C@@H](C)C4CCCCC4)=O)C=C2)=CN=C1
TargetTie-2,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

Tie2 Inhibitor 7 (orb1693504)

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1 mg
$ 880.00
5 mg
$ 3,300.00
DispatchUsually dispatched within 6-8 weeks
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