TIE-2/VEGFR-2 kinase-IN-5

SKU: orb1980178

Description

TIE-2/VEGFR-2 kinase-IN-5 is a dual inhibitor of TIE-2 and VEGFR-2 tyrosine kinases, exhibiting anti-angiogenic properties. It is widely utilized in angiogenesis research for both in vitro kinase assays and in vivo models of tumor growth and vascular development.

Research Area

Cardiovascular Research, Cardiovascular Research; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1014407-83-0
• MW: 481.35
• Purity: 99.79% (May vary between batches)
• Formula: C₂₁H₁₃F₆N₅O₂
• SMILES: O=C(NC=1C=CC(=CC1)C2=COC3=NC=NC(N)=C32)NC=4C=C(C=C(C4)C(F)(F)F)C(F)(F)F
• Target: VEGFR|||Tie-2

Bioactivity

• Target IC50:
  VEGFR2:8.11 nM|Tie2:7.78 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tie-2, Tie2, VEGFR2

Compound Identifiers

PubChem CID

23646936