Ticolubant

SKU: orb1699131

Description

Ticolubant is an orally bioavailable, potent antagonist of the leukotriene B4 (LTB4) receptor, exhibiting high binding affinity (Ki = 0.78 nM) and functional blockade of LTB4-induced calcium flux (IC50 = 6.6 nM). It has demonstrated topical anti-inflammatory efficacy in murine models of skin inflammation, supporting its research use in studying LTB4-mediated pathways in neutrophil-driven inflammatory diseases.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 154413-61-3
• MW: 460.37
• Purity: 99.59% (May vary between batches)
• Formula: C₂₃H₁₉Cl₂NO₃S
• SMILES: C(=C/C(O)=O)\C1=C(OCCC2=CC=CC=C2)C=CC(CSC3=C(Cl)C=CC=C3Cl)=N1
• Target: LTR,Leukotriene Receptor,Calcium Channel
• Solubility: DMSO:50 mg/mL (108.61 mM)

Bioactivity

• Target IC50:
  LTB4:0.78 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Calcium Channel, LTB4, Ticolubant

Compound Identifiers

PubChem CID

6441619