Tianeptine sodium salt

SKU: orb1305539

Description

Tianeptine sodium salt is an atypical antidepressant with a selective serotonin reuptake enhancer (SSRE) mechanism. It is utilized in preclinical research to model and investigate major depressive disorder in both in vitro neurochemical assays and in vivo behavioral studies.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 30123-17-2
• MW: 458.93
• Purity: 99.82% (May vary between batches)
• Formula: C₂₁H₂₄ClN₂NaO₄S
• SMILES: CN1c2ccccc2C(c2c(S1(=O)=O)cc(cc2)Cl)NCCCCCCC(=O)[O-].[Na+]
• Target: Opioid Receptor,MMP,Akt,iGluR,5-HT Receptor,PI3K,NF-κB
• Solubility: H2O:45.9 mg/mL (100.02 mM);DMSO:4.6 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.18 mM)

Bioactivity

• In Vitro:
  Tianeptine attenuates behavioral symptoms induced by peripheral, but not central, administration of LPS or IL-1β in rats. It normalizes the scaling ratio of NMDA receptor-mediated to AMPA/kainate receptor-mediated current amplitudes and prevents the stress-induced reduction in NMDA-EPSC inactivation. Tianeptine treatment prevents the increase in corticotropin-releasing factor (CRF) mRNA levels in the dBNST triggered by CMS and reduces CRF mRNA levels in the dBNST of non-stressed rats. In anesthetized rats, Tianeptine blocks stress-induced PB inhibition in the basolateral amygdala's CA1 region without affecting stress-induced LTP enhancement. Tianeptine administration under non-stress conditions enhances PB in the amygdala, hippocampus, and LTP in anesthetized rats. Tianeptine significantly decreases cell apoptosis in the rat temporal cortex and hippocampal dentate gyrus in both control and stressed animals but does not affect the Ammons horn. It notably increases extracellular concentrations of homovanillic acid and vanilmandelic acid in the nucleus accumbens and striatum. Intraperitoneal injection of 2.5 mg/kg Tianeptine in the nucleus accumbens alone increases extracellular dopamine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tianeptine sodium, Tianeptine sodium salt, Tianeptine, 5-HT, 5HTReceptor, 5-HT Receptor, 5HT Receptor

Compound Identifiers

PubChem CID

23663953