Tianeptine

SKU: orb1299185

Description

Tianeptine

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 72797-41-2
• MW: 436.95
• Purity: 98.00%
• Formula: C₂₁H₂₅ClN₂O₄S
• SMILES: N(CCCCCCC(O)=O)C1C=2C(S(=O)(=O)N(C)C=3C1=CC=CC3)=CC(Cl)=CC2
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.29 mM);DMSO:55 mg/mL (125.87 mM)

Bioactivity

• In Vivo:
  tianeptine pretreatment upon corticosterone release and body weight loss following L-5 hydroxytryptophan (5 hTP) administration in conscious rats. Administration of 5 hTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min before and).?Besides, prior administration of benserazide (50 mg/kg i.p., 30 min before and), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5 hTP-induced corticosterone release In both saline- and tianeptine-pretreated rats. however, combined administration of benserazide and 5 hTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats. These results suggest that tianeptine preferentially activates 5 hT reuptake in central serotonergic neurones.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

5-HT, 5HTReceptor, 5-HT Receptor, 5HT Receptor, JNJ 39823277, JNJ39823277, JNJ-39823277, Tianeptine, S1574, S-1574, S 1574, TPI-1062, TPI1062, TPI 1062

Compound Identifiers

PubChem CID

68870