Tiamulin fumarate

SKU: orb1909127

Description

Tiamulin fumarate is a semisynthetic diterpenoid antibiotic that inhibits bacterial protein synthesis. It is widely used in research applications, including in vitro and in vivo studies of pathogens like Pneumocystis and swine dysentery-causing bacteria.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 55297-96-6
• MW: 609.81
• Purity: 99.64% (May vary between batches)
• Formula: C₃₂H₅₁NO₈S
• SMILES: OC(=O)\C=C\C(O)=O.[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CSCCN(CC)CC
• Target: Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.41 mM);H2O:80 mg/mL (131.19 mM);DMSO:250 mg/mL (409.96 mM)

Bioactivity

• In Vivo:
  Tiamulin is highly effective in treating swine dysentery in both breeding and laying hens, with significant efficacy against B. pilosicoli and B. intermedia at a dose of 25 mg/kg body weight per day for 5 consecutive days .
• In Vitro:
  Tiamulin exhibits high activity against mycoplasma strains (Gloss M. gallisepticum, M. synoviae, M. meleagridis, and M. iowae), spirochetes (Brachyspira hyodysenteriae, Brachyspira innocens, B. pilosicoli, B. intermedia), and Gram-positive bacteria (Staphylococcus, Streptococcus, Clostridium, and Campylobacter spp), but its activity against Gram-negative bacteria (Bordetella, Klebsiella, Haemophilus, Clostridium, Campylobacter, and Corynebacterium spp) is relatively low.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thiamutilin fumarate, Tiamulin fumarate, Antibacterial

Compound Identifiers

PubChem CID

23725049