Tiamulin fumarate

SKU: orb1909127

Description

Tiamulin fumarate is a semisynthetic diterpenoid antibiotic that inhibits bacterial protein synthesis. It is widely used in research applications, including in vitro and in vivo studies of pathogens like Pneumocystis and swine dysentery-causing bacteria.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 55297-96-6
• MW: 609.82
• Purity: 99.69% (May vary between batches)
• Formula: C₃₂H₅₁NO₈S
• SMILES: C(=C/C(O)=O)\C(O)=O.C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CSCCN(CC)CC)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]
• Target: Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.41 mM);H2O:80 mg/mL (131.19 mM);DMSO:250 mg/mL (409.96 mM)

Bioactivity

• In Vivo:
  Tiamulin is highly effective in treating swine dysentery in both breeding and laying hens, with significant efficacy against B. pilosicoli and B. intermedia at a dose of 25 mg/kg body weight per day for 5 consecutive days .
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• In Vitro:
  Tiamulin exhibits high activity against mycoplasma strains (Gloss M. gallisepticum, M. synoviae, M. meleagridis, and M. iowae), spirochetes (Brachyspira hyodysenteriae, Brachyspira innocens, B. pilosicoli, B. intermedia), and Gram-positive bacteria (Staphylococcus, Streptococcus, Clostridium, and Campylobacter spp), but its activity against Gram-negative bacteria (Bordetella, Klebsiella, Haemophilus, Clostridium, Campylobacter, and Corynebacterium spp) is relatively low.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thiamutilin fumarate, Tiamulin fumarate, Antibacterial

Compound Identifiers

PubChem CID

23725049