Thymectacin

SKU: orb1702727

Description

Thymectacin (NB 1011) is a selective thymidylate synthase (TS) inhibitor developed as an anticancer agent. Its activity has been investigated in preclinical studies for colon cancer and other solid tumors, demonstrating effects in both cellular and animal models of disease.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 232925-18-7
• MW: 574.32
• Purity: 99.82% (May vary between batches)
• Formula: C₂₁H₂₅BrN₃O₉P
• SMILES: O=C1N(C=C(/C=C/Br)C(=O)N1)[C@@H]2O[C@H](COP(OC3=CC=CC=C3)(N[C@H](C(OC)=O)C)=O)[C@@H](O)C2
• Target: DNA/RNA Synthesis
• Solubility: DMSO:80 mg/mL(139.30 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.48 mM)

Bioactivity

• Target IC50:
  HT115 cells:245 μM (EC50)|MDA-MB-231 cells:79 μM (EC50)|PC3 cells:155 μM (EC50)
• In Vitro:
  The main clinical candidate, Thymectacin, showed only moderate activity in vitro, with EC50 values ranging from 79-245 μM in our assay. However, relatively minor structural adjustments resulted in a significant increase in potency.MDA-MB 231 EC50=79 μM, HT 115 EC50=245 μM, and PC-3 EC50=155 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, NB 1011, NB1011, NB-1011, RNA Synthesis, RNASynthesis, Thymectacin, Thymidine synthase

Compound Identifiers

PubChem CID

6440764