α-Thujone

SKU: orb1299134

Description

α-Thujone is a small molecule inhibitor of acetylcholinesterase (AChE) with an IC50 of 24.7 µM. It is used in neuroscience research to study cholinergic signaling and has been investigated in vitro for its neuroactive properties.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 546-80-5
• MW: 152.23
• Purity: 98.41% (May vary between batches)
• Formula: C₁₀H₁₆O
• SMILES: [H][C@]12C[C@]1(CC(=O)[C@@H]2C)C(C)C
• Target: AChR,Autophagy,Parasite,ROS,Reactive Oxygen Species,GABA Receptor,Apoptosis
• Solubility: DMSO:4.4 mg/mL (28.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.57 mM)

Bioactivity

• Target IC50:
  α7 nAChR:24.7μM
• In Vitro:
  In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, a-Thujone, Autophagy, anthelmintic, antinociceptive, anti-invasive, anti-tumor, ALPHA-(-)-THUJONE, ALPHA-THUJONE, BBB, AChR, GABAReceptor, GABA Receptor, GABAA, Gamma-aminobutyric acid Receptor, insecticidal, Parasite, Inhibitor, inhibit, Monoterpene, α Thujone, αThujone, α-Thujone, γ-Aminobutyric acid Receptor, ROS, stress, oxidative, Thujone, ReactiveOxygenSpecies, Reactive Oxygen Species, pro-apoptotic

Compound Identifiers

PubChem CID

261491