THR-β agonist 9

SKU: orb3135097

Description

THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2920045-74-3
• MW: 418.40
• Formula: C₂₃H₁₈N₂O₆
• SMILES: O=C(O)CNC(=O)C1=NC(OC)=C2C=C(OC=3C=CC=4C=CC=CC4C3)C=CC2=C1O
• Target: Mitochondrial Metabolism,Acetyl-CoA Carboxylase,Thyroid hormone receptor(THR),AMPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism,Acetyl-CoA Carboxylase,Thyroid hormone receptor(THR),AMPK