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THR-β agonist 6
Catalog Number: orb1982622
| Catalog Number | orb1982622 |
|---|---|
| Category | Small Molecules |
| Description | THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remarkable liver-to-serum ratio of 93:1 in mouse models, underscoring its efficacy and potential for research in nonalcoholic steatohepatitis (NASH) [1]. |
| Purity | 98.00% |
| MW | 457.27 |
| Biological Activity | THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remarkable liver-to-serum ratio of 93:1 in mouse models, underscoring its efficacy and potential for research in nonalcoholic steatohepatitis (NASH) [1]. |
| CAS Number | 2791290-58-7 |
| Formula | C20H14Cl2N6O3 |
| SMILES | ClC1=C(N2C3=C(C=C2)N(C(C)C)C(=O)C=C3)C(Cl)=CC(=C1)N4N=C(C#N)C(=O)NC4=O |
| Storage | -20°C |
| Note | For research use only |
MGL-3196 [orb1223645]
> 98% (HPLC)
920509-32-6
435.2
C17H12Cl2N6O4
1 g, 500 mg, 100 mg, 10 mg, 25 mg, 50 mg, 2 mg, 5 mg
