Thioquinapiperifil dihydrochloride

SKU: orb2900251

Description

Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.

Key Properties

• CAS Number: 204077-66-7
• MW: 485.05
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₉ClN₆OS
• SMILES: Cl.Cl.CCn1c2cc3ncnc(NCc4ccccc4N4CCC(CO)CC4)c3cc2[nH]c1=S
• Target: PDE
• Solubility: In Vitro: DMSO : 125 mg/mL (239.69 mM; Ultrasonic )

Bioactivity

• In Vitro:
  Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil dihydrochloride (KF31327) are required to inhibit platelet aggregation. Thioquinapiperifil dihydrochloride (KF31327) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil dihydrochloride (KF31327)-treated cells is 0.95±0.17 pmol/108 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE