Thiomyristoyl

SKU: orb1304194

Description

Thiomyristoyl is a potent and highly selective SIRT2 inhibitor with an IC50 of 28 nM, showing over 3,500-fold selectivity against SIRT1 and no activity against SIRT3. This inhibitor is a valuable chemical probe for studying SIRT2's role in cancer, neurodegenerative diseases, and aging in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1429749-41-6
• MW: 581.85
• Purity: 99.16% (May vary between batches)
• Formula: C₃₄H₅₁N₃O₃S
• SMILES: CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1
• Target: Sirtuin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.87 mM);Chloroform:Soluble;DMSO:100 mg/mL (171.87 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  SIRT2:28 nM|SIRT1:98 μM
• In Vivo:
  Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl.
• In Vitro:
  In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels.
• Cell Research:
  Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thiomyristoyl, SIRT1, SIRT2, Sirtuin, inhibit, Inhibitor

Compound Identifiers

PubChem CID

126843233