ThioLox

SKU: orb1745219

Description

ThioLox is a potent and competitive 15-LOX-1 inhibitor (IC50 = 12 µM) with demonstrated neuroprotective and anti-inflammatory properties. It has shown protective effects against glutamate-induced toxicity in cellular models, supporting its research utility in studying oxidative stress and neuroinflammation pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1202193-89-2
• MW: 274.38
• Purity: 100.00% (May vary between batches)
• Formula: C₁₅H₁₈N₂OS
• SMILES: C(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2
• Target: Lipoxygenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM);DMSO:90 mg/mL (328.01 mM)

Bioactivity

• Target IC50:
  15-LOX1:3.3 (Ki)
• In Vivo:
  The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier.
• In Vitro:
  ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

15 LOX, ThioLox

Compound Identifiers

PubChem CID

53383638