Thiodigalactoside

SKU: orb1692331

Description

Thiodigalactoside (TDG) is a potent, orally bioavailable galectin-1 and galectin-3 inhibitor with Kd values of 24 µM and 49 µM, respectively. It exhibits anti-inflammatory and anti-cancer properties in vitro and has been shown to reduce body weight gain in diet-induced obese rat models in vivo.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 51555-87-4
• MW: 358.36
• Purity: 99.90% (May vary between batches)
• Formula: C₁₂H₂₂O₁₀S
• SMILES: OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
• Target: Galectin
• Solubility: H2O:90 mg/mL (251.14 mM);DMF:1 mg/mL (2.79 mM);DMSO:50 mg/mL (139.52 mM);PBS (pH 7.2):10 mg/mL (27.9 mM)

Bioactivity

• Target IC50:
  GAL3:49 μM (Kd)|GAL1:24 μM (Kd)
• In Vivo:
  Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) significantly inhibits HFD-induced body weight gain, whereas oral administration (5 mg/kg; daily or weekly for 5 weeks) provides less reduction in body weight gain compared to IP administration .
  Read more...
• In Vitro:
  Thiodigalactoside (TDG; 250 and 500 μM) demonstrates a dose-dependent decrease in fat accumulation, as evidenced by reductions in triglyceride (TG) content and Oil Red O (ORO) staining.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thiodigalactoside, Galectin

Compound Identifiers

PubChem CID

119138