Theobromine

SKU: orb1310438

Description

Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid with bronchodilator and vasodilator properties. It is widely used in research applications, including in vitro studies of phosphodiesterase inhibition and in vivo models investigating cardiovascular and respiratory physiology.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 83-67-0
• MW: 180.16
• Purity: 99.63% (May vary between batches)
• Formula: C₇H₈N₄O₂
• SMILES: CN1C2=C(C(=O)NC1=O)N(C)C=N2
• Target: Endogenous Metabolite,PDE,Adenosine Receptor
• Solubility: DMSO:0.45 mg/mL (2.5 mM)

Bioactivity

• In Vivo:
  LD50: Rabbits >200 mg/kg (i.g.)
• In Vitro:
  Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. Unlike caffeine, Theobromine has practically no stimulant effect on the central nervous system. In contrast, It may improve mood and cognition via peripheral physiological changes. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, Inhibitor, inhibit, PDE, AdenosineReceptor, Adenosine Receptor, Adenosine receptor, 3,7-Dimethylxanthine, 3, 7-Dimethylxanthine, Endogenous Metabolite, P1 receptor, Theobromine

Compound Identifiers

PubChem CID

5429