Theaflavin 3,3′-digallate

SKU: orb1301797

Description

Theaflavin 3,3'-digallate

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 30462-35-2
• MW: 868.70
• Purity: 99.20%
• Formula: C₄₃H₃₂O₂₀
• SMILES: Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c2c1cc(cc(O)c2=O)[C@H]1Oc2cc(O)cc(O)c2C[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
• Target: Virus Protease,HSV,Anti-infection,Antioxidant,HIV Protease
• Solubility: DMSO:117.50 mg/mL (135.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.00 mg/mL (1.15 mM);Ethanol:10.00 mg/mL (11.51 mM)

Bioactivity

• In Vivo:
  in vivo Theaflavin 3,3'-digallatereduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening o the alveolar All in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion an the number of mature osteoclasts in mice in a dose-dependent manner.
• In Vitro:
  Theaflavin 3,3'-digallate (TF-3) significantly reduces viral RNA levels an the expression of NS3 and U87 MG proteins in a dose-dependent manner when used at concentration of 6.25, 12.5, and 25 μM for 24 hours. Theaflavin 3,3'-digallate demonstrates potent antiviral activity against ZIKV replication in Vero E6 cells (EC50: 7.65 μM), while showing minimal cytotoxicity at doses up to 40 μM. Theaflavin 3,3'-digallate interferes wit the post-entry phases o the ZIKV replication cycle, disrupting gene transcription and translation. Theaflavin 3,3'-digallate leads to a rapid and sustained reduction in phospho-ERK1/2 and phospho-MEK1/2 protein levels and inhibits HCT116 cell growth IC50 17.26 μM).

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Akt, 8-Gingerol, 0, Antioxidant, inhibit, NS3, NS2B-3, p53, NF-κB, p21, Inhibitor, HIVProtease, HIV Protease, HIV, Herpes simplex virus, MAPK, gp41, HSV, Human immunodeficiency virus, ERK1/2, translation, ZP 10, ZP10, ZP-10, U87, TF 3, TF3, TF-3, TFDG, replication, Theaflavin 3, Theaflavin 3,3' digallate, Theaflavin 3,3′-di-O-gallate, Theaflavin 3,3'digallate, Theaflavin 3,3'-digallate, ZIKV, VirusProtease, Virus Protease

Compound Identifiers

PubChem CID

467320