Thalidomide-O-COOH

SKU: orb1299537

Description

Thalidomide-O-COOH (Cereblon ligand 3) is a derivative of thalidomide designed to bind the CRBN E3 ubiquitin ligase. It serves as a key recruiting moiety in PROTACs for targeted protein degradation, a tool widely used in both in vitro biochemical assays and in vivo target validation studies in cancer and disease research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1061605-21-7
• MW: 332.27
• Purity: 98.29%
• Formula: C₁₅H₁₂N₂O₇
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(O)=O
• Target: Ligands for E3 Ligase,Autophagy,Apoptosis
• Solubility: DMSO:42 mg/mL (126.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thalidomide O COOH, TCE 35031, TCE35031, TCE-35031, ThalidomideOCOOH, Thalidomide-O-COOH, E3 ligase Ligand 3, Cereblon, Cereblon ligand3, Cereblon ligand-3, Cereblon ligand 3, inhibit, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, Inhibitor, E3 ligase-recruiting Moiety

Compound Identifiers

PubChem CID

25015436