Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

SKU: orb1307272

Description

This bifunctional molecule incorporates a thalidomide-based E3 ligase ligand connected via a PEG2-C2 linker. It serves as a key component in PROTAC development for targeted protein degradation, with research applications in cancer immunology and oncology, including studies in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2376990-30-4
• MW: 498.914
• Purity: 99.57% (May vary between batches)
• Formula: C₂₁H₂₇ClN₄O₈
• SMILES: O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
• Target: Apoptosis,Autophagy,Ligands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates

Bioactivity

• In Vitro:
  PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, E3 Ligase Ligand-Linker Conjugates, Cereblon, ThalidomideOamidoPEG2C2NH2 hydrochloride, Thalidomide-O-amido-PEG-2-C2-NH2 hydrochloride, Thalidomide-O-amido-PEG2-C2-NH2 Hydrochloride, Thalidomide O amido PEG2 C2 NH2 hydrochloride

Compound Identifiers

PubChem CID

145874885