Thalidomide-O-amido-C4-N3

SKU: orb1308357

Description

This compound is a cereblon E3 ligase ligand-linker conjugate based on a Thalidomide derivative. It serves as a key component in the construction of PROTACs for targeted protein degradation, a tool widely used in both in vitro and in vivo cancer and disease mechanism research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2098488-36-7
• MW: 428.4
• Purity: 97.01% (May vary between batches)
• Formula: C₁₉H₂₀N₆O₆
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCN=[N+]=[N-])=O
• Target: Ligand for E3 Ligase
• Solubility: DMSO:40 mg/mL (93.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cereblon, Cereblon Ligand-Linker Conjugates 4, E3 Ligase Ligand-Linker Conjugates, E3 ligase Ligand-Linker Conjugates 18, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, Thalidomide O amido C4 N3, ThalidomideOamidoC4N3, Thalidomide-O-amido-C-4-N3, Thalidomide-O-amido-C4-N3

Compound Identifiers

PubChem CID

131704500