Thalidomide-5-OH

SKU: orb1298209

Description

Thalidomide-5-OH is a cereblon (CRBN)-binding ligand derived from thalidomide, used to construct PROTAC molecules for targeted protein degradation. This small molecule enables the study of CRBN-recruiting PROTACs in both cellular and in vivo models for probing disease-related protein functions.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64567-60-8
• MW: 274.23
• Purity: 98.94%
• Formula: C₁₃H₁₀N₂O₅
• SMILES: O=C1N(C(=O)C=2C1=CC(O)=CC2)C3C(=O)NC(=O)CC3
• Target: Apoptosis,Autophagy,Ligands for E3 Ligase
• Solubility: DMSO:60 mg/mL (218.79 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.29 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CRBN, E3 ligase-recruiting Moiety, 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, PROTAC, Thalidomide, Thalidomide 5 OH, Thalidomide5OH, Thalidomide-5-OH

Compound Identifiers

PubChem CID

5743568